Prostamax (20 mg Vial) Dosage Protocol
Quickstart Highlights
Prostamax is a synthetic tetrapeptide bioregulator (Lys-Glu-Asp-Pro / KEDP) derived from prostate tissue peptide complex research[1][2]. Short peptides of this class have been studied for their ability to modulate gene expression through epigenetic interactions with chromatin and histones[3][4]. This educational protocol presents a once‑daily intramuscular approach using a practical dilution for clear insulin‑syringe measurements.
- Reconstitute: Add 2.0 mL bacteriostatic water → 10 mg/mL concentration.
- Typical daily range: 500 mcg–1 mg once daily (gradual titration).
- Easy measuring: At 10 mg/mL, 1 unit = 0.01 mL = 100 mcg (0.1 mg) on a U‑100 insulin syringe.
- Storage: Lyophilized: refrigerate at 4 °C (39.2 °F) short‑term or freeze at −20 °C (−4 °F) long‑term; after reconstitution, refrigerate at 2–8 °C (35.6–46.4 °F) and use within 2 weeks.
Dosing & Reconstitution Guide
Educational guide for reconstitution and daily dosing
Standard / Gradual Approach (2 mL = 10 mg/mL)
Route: Intramuscular (IM) injection once daily[1][2]
| Phase / Week | Daily Dose (mcg / mg) | Units (per injection) (mL) |
|---|---|---|
| Weeks 1–2 | 500 mcg (0.5 mg) | 5 units (0.05 mL) |
| Weeks 3–4 | 750 mcg (0.75 mg) | 7.5 units (0.075 mL) |
| Weeks 5–8 | 1,000 mcg (1 mg) | 10 units (0.10 mL) |
| Weeks 9–12 (optional extension) | 1,000 mcg (1 mg) | 10 units (0.10 mL) |
Frequency: Inject once daily intramuscularly. Preclinical studies used daily IM administration for 15–60 days[1][2]. For administrations ≤10 units (≤0.10 mL), consider 30‑ or 50‑unit insulin syringes for improved readability.
Reconstitution Steps
- Draw 2.0 mL bacteriostatic water with a sterile syringe.
- Inject slowly down the vial wall; avoid foaming.
- Gently swirl/roll until dissolved (do not shake).
- Label and refrigerate at 2–8 °C (35.6–46.4 °F), protected from light; use within 2 weeks.
Supplies Needed
Plan based on an 8–16 week daily protocol with gradual titration.
-
Peptide Vials (Prostamax, 20 mg each):
- 8 weeks ≈ 2 vials (~40 mg total at ~0.7 mg/day average)
- 12 weeks ≈ 3 vials (~60 mg total)
- 16 weeks ≈ 4 vials (~80 mg total at ~1 mg/day maintenance)
-
Insulin Syringes (U‑100, 30‑ or 50‑unit recommended for precision):
- Per week: 7 syringes (1/day)
- 8 weeks: 56 syringes
- 12 weeks: 84 syringes
- 16 weeks: 112 syringes
-
Bacteriostatic Water (10 mL bottles): Use 2.0 mL per vial for reconstitution.
- 8 weeks (2 vials): 4 mL → 1 × 10 mL bottle
- 12 weeks (3 vials): 6 mL → 1 × 10 mL bottle
- 16 weeks (4 vials): 8 mL → 1 × 10 mL bottle
-
Alcohol Swabs: One for the vial stopper + one for the injection site each day.
- Per week: 14 swabs (2/day)
- 8 weeks: 112 swabs → recommend 2 × 100‑count boxes
- 12 weeks: 168 swabs → recommend 2 × 100‑count boxes
- 16 weeks: 224 swabs → recommend 3 × 100‑count boxes
Protocol Overview
Concise summary of the once‑daily regimen.
- Goal: Support prostate tissue health and function through bioregulatory peptide signaling[1][2].
- Schedule: Daily intramuscular injections for 8–12 weeks (extend to 16 weeks if desired).
- Dose Range: 500 mcg–1 mg daily with gradual titration.
- Reconstitution: 2.0 mL per 20 mg vial (10 mg/mL) for accurate unit measurements.
- Storage: Lyophilized refrigerated or frozen; reconstituted refrigerated; use within 2 weeks.
Dosing Protocol
Suggested daily titration approach.
- Start: 500 mcg (0.5 mg) daily; increase by ~250 mcg every 2 weeks as tolerated.
- Target: 1 mg daily by Weeks 5–8.
- Frequency: Once per day (intramuscular).
- Cycle Length: 8–12 weeks; optional extension to 16 weeks.
- Timing: Any consistent time; rotate injection sites among large muscle groups.
Storage Instructions
Proper storage preserves peptide quality[8].
- Lyophilized (short‑term): Refrigerate at 4 °C (39.2 °F) in dry, dark conditions.
- Lyophilized (long‑term): Store at −20 °C (−4 °F) for extended stability.
- Reconstituted: Refrigerate at 2–8 °C (35.6–46.4 °F); use within ~2 weeks and avoid freeze–thaw cycles.
- Allow vials to reach room temperature before opening to reduce condensation uptake.
Important Notes
Practical considerations for consistency and safety.
- Use new sterile insulin syringes or appropriate IM syringes; dispose in a sharps container.
- Rotate injection sites among large muscle groups (deltoid, vastus lateralis, gluteus) to reduce local irritation[5].
- Inject slowly; wait a few seconds before withdrawing the needle.
- For volumes ≤10 units, use 30‑ or 50‑unit syringes for better precision.
- Document daily dose and site rotation to maintain consistency.
How This Works
Prostamax (KEDP) belongs to the class of short bioregulatory peptides studied by Khavinson and colleagues. These tetrapeptides are proposed to modulate gene expression through epigenetic mechanisms, interacting with chromatin structure and histone proteins[3][4]. In aged human lymphocytes, KEDP has been observed to cause pericentromeric chromatin decondensation, potentially reactivating suppressed genes[3]. Preclinical rat models of prostatitis showed that IM administration of KEDP reduced inflammatory markers and helped prevent fibrotic changes in prostate tissue[1][2].
Potential Benefits & Side Effects
Observations from preclinical literature (no published human trials).
- In rat prostatitis models, IM KEDP administration reduced inflammation and supported tissue normalization over treatment periods of 15–60 days[1].
- Studies in benign prostatic hyperplasia (BPH) models showed favorable effects on prostate weight and histological parameters[2].
- Short bioregulatory peptides of this class generally show favorable tolerability profiles in preclinical work[4].
- Potential for mild injection‑site reactions (redness, tenderness) as with any IM administration; rotate sites to minimize.
- Note: Human clinical trial data are not yet published; dosing is extrapolated from animal models.
Lifestyle Factors
Complementary strategies for prostate health.
- Maintain a balanced diet rich in vegetables, healthy fats, and adequate protein.
- Regular physical activity supports circulation and overall metabolic health.
- Adequate hydration and limiting alcohol/caffeine may support urinary function.
- Prioritize sleep and stress management to support immune and hormonal balance.
Injection Technique
Intramuscular administration guidance from clinical best‑practice resources[5][10].
- Clean the vial stopper and skin with alcohol; allow to dry completely.
- For IM injection, use a 22–25 gauge, 1–1.5 inch needle inserted at 90° into a large muscle (deltoid, vastus lateralis, or gluteus)[5].
- Aspiration before IM injection is no longer routinely recommended for most sites[7].
- Inject slowly and steadily; wait briefly before withdrawing.
- Rotate sites systematically to avoid muscle irritation or fibrosis[9].
- Alternative (SC): If subcutaneous route is preferred, use a 23–25 gauge, 5/8 inch needle at 45° into fatty tissue[6].
Recommended Source
We recommend Pure Lab Peptides for high‑purity Prostamax (20 mg).
Why Pure Lab Peptides?
- High‑purity, third‑party‑tested lots with batch COAs.
- Consistent, ISO‑aligned handling and documentation.
- Reliable fulfillment to maintain cold‑chain integrity.
Important Note
This content is for educational purposes only and is not medical advice. No human clinical trials have been published for Prostamax; all dosing is extrapolated from preclinical research.
References
-
Modern Research in Inflammation (2013)
— Experimental study of Prostamax efficiency in chronic aseptic prostatitis therapy and complications -
Modern Research in Inflammation (2014)
— Experimental study of tetrapeptide Lysyl-Glutamyl-Aspartyl-Proline in benign prostatic hyperplasia model -
Bulletin of Experimental Biology and Medicine (2004)
— Effects of short peptides on lymphocyte chromatin in senile subjects (KEDP and chromatin decondensation) -
Stem Cell Reviews and Reports (2020)
— Peptide regulation of cell differentiation: epigenetic mechanisms of short bioregulatory peptides -
CDC
— Vaccine administration: Intramuscular (IM) injection guidelines for adults -
CDC (Subcut Injection PDF)
— Technique diagram and site guidance for subcutaneous injections -
CDC
— Vaccine administration: During vaccination (aspiration guidance, aseptic technique) -
NIBSC (MHRA)
— Peptide handling, dissolution, and storage best practices -
NCBI Bookshelf
— Best practices for injection (asepsis, preparation, and administration) -
CDC
— General best practices for immunization: injection technique and safety -
Subcutaneous Drug Injection Review (PMC)
— Pharmacologic considerations of the subcutaneous route -
Pure Lab Peptides
— Prostamax (20 mg) product page (quality and batch documentation)