Melanotan II (10 mg Vial) & PT-141 (10 mg Vial) Dosage Protocol
Quickstart Highlights
Stack Melanotan II and PT-141 for synergistic tanning and libido enhancement.
- Melanotan II: 0.25–0.5 mg per injection, 2×/week for 4 weeks
- PT-141: 1.75 mg per injection, as-needed (max 1/24 h, ≤ 8/mo)
- Typical Melanotan II cycle: 4 weeks; PT-141 is on-demand
- Reconstitute each vial with bacteriostatic water (max 3 mL)
- Store the reconstituted solution at 2–8 °C (refrigerator), protected from light.
Dosing & Reconstitution Guide
Educational guide for reconstitution and dosing protocol
Melanotan II (10 mg Vial): Standard/Gradual Approach
Reconstitute with 3 mL bacteriostatic water → 3.33 mg/mL. (Max 3 mL per vial.)
| Week | Dosage | Units (mL) | Frequency |
|---|---|---|---|
| Weeks 1–2 | 250 mcg (0.25 mg) | ~7.5 units (0.075 mL) use 30 or 50-unit syringe |
2× per week |
| Weeks 3–4 | 500 mcg (0.5 mg) | ~15 units (0.15 mL) | 2× per week |
Note: Even at 3 mL dilution, Week 1 injections are <10 units; a smaller (30/50-unit) syringe improves accuracy.
- Draw 3.0 mL bacteriostatic water into a sterile syringe.
- Inject slowly against vial wall; avoid vigorous shaking.
- Swirl gently until dissolved; label with date.
- Store the reconstituted solution at 2–8 °C (refrigerator), protected from light.
PT-141 (10 mg Vial): On-Demand Protocol
Reconstitute with 1 mL bacteriostatic water → 10 mg/mL.
| Use Case | Dosage | Units (mL) | Frequency |
|---|---|---|---|
| Female HSDD | 1.75 mg (1750 mcg) | ~18 units (0.18 mL) | As needed, ≥45 min before sex Max 1/24 h, ≤ 8/mo |
| Male ED (off-label) | 1.0–2.0 mg | 10–20 units | As needed, 30–60 min before sex Max 1/24 h, ≤ 8/mo |
- Draw 1.0 mL bacteriostatic water into a sterile syringe.
- Inject gently; swirl to dissolve; label and refrigerate.
- Store the reconstituted solution at 2–8 °C (refrigerator), protected from light.
Stack Administration
Administer both peptides on same day if desired—use separate syringes and injection sites; do not mix in one syringe.
- Melanotan II injections on two consistent days/week (e.g., Mon & Thu)
- PT-141 on-demand before sexual activity
- Maintain injection logs to track dose and effects
Protocol Overview
4-week tanning cycle with Melanotan II plus on-demand PT-141 for libido.
- Melanotan II: 0.25–0.5 mg/inj, 2× weekly
- PT-141: 1.75 mg/inj, as needed (max 1/24 h, ≤ 8/mo)
- Cycle Length: Melanotan II: 4 weeks; PT-141: flexible
- Reconstitution: Melanotan II: 3 mL; PT-141: 1 mL
Storage Instructions
Preserve potency by proper handling.
- Lyophilized: Keep frozen until reconstitution
- Reconstituted: Store the reconstituted solution at 2–8 °C (refrigerator), protected from light.
Supplies Needed
Materials for a 4-week Melanotan II cycle + PT-141.
- Peptide Vials:
• Melanotan II (10 mg Vial) – Product ID: 1049 (need 2 vials for 4-wk cycle)
• PT-141 (10 mg Vial) – Product ID: 1044 (1 vial covers ≤ 8 doses) - Insulin Syringes: 30-unit & 100-unit sizes
- Bacteriostatic Water: 1× 30 mL bottle
- Alcohol Swabs: 1 box
Important Notes
Safety and consistency tips.
- Use new, sterile syringes each injection; rotate sites.
- Keep detailed injection log (dose, date, effects).
- Monitor for nausea, flushing, blood pressure changes.
- Do not mix peptides in same syringe.
How This Works
Peptide actions underpin protocol.
- Melanotan II: Activates MC1R → melanin synthesis (tanning), MC3/4R → libido effects.
- PT-141: Activates MC4R in CNS → sexual arousal and desire.
- Separate mechanisms yield complementary outcomes.
Potential Benefits & Side Effects
Research-backed outcomes with caution.
- Enhanced baseline tan; reduced UV damage sensitivity
- Improved sexual desire and erectile function
- Mild side effects: nausea, facial flushing, headache
- Monitor for pigment changes (moles), blood pressure elevations
Lifestyle Factors
Optimize results with healthy habits.
- Use sunscreen during tanning cycle
- Stay hydrated; light exercise supports circulation
- Time PT-141 injections 45–60 min before activity
Injection Technique
Simple guidelines for safe daily injections.
- Clean vial rubber stopper & injection site with alcohol swabs
- Insert needle at a 45–90° angle into subcutaneous tissue
- Inject slowly & rotate sites (abdomen, thigh, etc.)
Recommended Source
We recommend Pure Lab Peptides for high-purity BPC-157 + TB-500 blend.
Why Pure Lab Peptides?
- Verifies ≥99% purity through independent lab testing
- Trusted by researchers seeking reliable results
- Follows rigorous manufacturing standards for consistent quality
Important Note
This guide is for educational purposes only. Always consult a qualified healthcare provider before starting or modifying any therapy.
References
-
PubMed
– Melanotan II phase-I human study -
PubMed
– Bremelanotide early clinical efficacy trial -
PMC
– Bremelanotide Phase-3 HSDD review -
PMC
– Melanocortin analogs systematic overview -
FDA Document
– Bremelanotide NDA 210557 package -
ClinicalTrials.gov
– PT-141 efficacy registry study -
ScienceDirect
– Melanotan II pharmacology article -
British J Dermatology
– Melanocortin receptor stimulation findings -
Karger Dermatology
– Melanotan II user-experience study -
ScienceDirect
– Peptide pharmacokinetics research article -
Taylor & Francis
– Pharmaceutical medicine review on MT-2 -
PubMed
– Injection-site technique safety review -
ScienceDirect
– Subcutaneous delivery factors study -
TGA Australia
– Safety alert on Melanotan products -
PMC
– Melanocortin peptides comprehensive review -
HPRA Ireland
– Health risk notice on MT-2 -
MedlinePlus
– Bremelanotide drug information sheet -
DrugBank
– Bremelanotide molecule database entry -
JAMA Dermatology
– Adverse events with MT-2 use -
University of Michigan
– Subcutaneous injection patient guide -
MedlinePlus
– Patient instructions for SC injections -
PMC
– Melanocortin receptor pharmacology review -
Frontiers Neuroscience
– Behavioral effects of melanocortins -
Wiley J Clin Pharm
– PT-141 population-PK analysis -
PMC
– Melanotan systemic safety evaluation -
ScienceDirect
– Bremelanotide receptor binding study